Side Effects | ESTRING® (estradiol vaginal ring) | Safety Info

Risk Factors and Side Effects

It’s important to talk to your doctor regularly (every 3 to 6 months) about whether you should continue using ESTRING® (estradiol vaginal ring). See your doctor right away if you experience vaginal bleeding when using ESTRING.

If you have fever, nausea, vomiting, diarrhea, muscle pain, dizziness, faintness, or a sunburn-like rash on your face and body, remove ESTRING and contact your healthcare professional. Contact your healthcare professional if you have trouble removing the vaginal ring.

 

Side Effects and Risk Factors

What is the Most Important Information I Should Know About ESTRING
(an Estrogen Hormone)?

  • Estrogens increase the chance of getting cancer of the uterus. Report any unusual vaginal bleeding right away while you are using ESTRING. Vaginal bleeding after menopause may be a warning sign of cancer of the uterine (womb). Your healthcare provider should check any unusual vaginal bleeding to find out the cause.
  • Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women age 65 years or older. You and your healthcare provider should talk regularly about whether you still need treatment with ESTRING.

Do Not Start Using ESTRING if You:

  • Have unusual vaginal bleeding
  • Currently have or have had certain cancers
    Estrogens may increase the chance of getting certain types of cancers, including cancer of the breast or uterus. If you have or have had cancer, talk with your healthcare provider about whether you should use ESTRING.
  • Had a stroke or heart attack in the past year
  • Currently have or have had blood clots
  • Currently have or have had liver problems
  • Are allergic to any of the ingredients in ESTRING (See the list of ingredients in ESTRING in the Patient and Prescribing Information)
  • Think you may be pregnant

Tell Your Doctor or Healthcare Professional:

  • If you are breastfeeding. The hormone in ESTRING can pass into your breast milk
  • About all of your medical problems. Your healthcare professional may need to check you more carefully if you have certain conditions, such as asthma (wheezing), epilepsy (seizures), migraine, endometriosis, lupus, or problems with your heart, liver, thyroid, kidneys, or have high calcium levels in your blood
  • About all the medicines you take, such as prescription and nonprescription medicines, vitamins, and herbal supplements
  • If you are going to have surgery or will be on bed rest. You may need to stop using estrogens

What Are the Possible Side Effects of Estrogens?

Side effects are grouped by how serious they are and how often they happen when you are treated.
Serious but less common side effects include:

  • Breast cancer
  • Cancer of the uterus
  • Stroke
  • Heart attack
  • Blood clots
  • Dementia
  • Gallbladder disease
  • Ovarian cancer
  • High blood pressure
  • Liver problems
  • High blood sugar
  • Enlargement of benign tumors of the uterus (“fibroids”)

Some of the warning signs of these serious side effects include:

  • Breast lumps
  • Unusual vaginal bleeding
  • Dizziness and faintness
  • Changes in speech
  • Severe headaches
  • Chest pain
  • Shortness of breath
  • Pains in your legs
  • Changes in vision
  • Vomiting
  • Yellowing of the skin, eyes or nail beds

Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

Less serious but common side effects include:

  • Headache
  • Breast pain
  • Irregular vaginal bleeding or spotting
  • Stomach/abdominal cramps, bloating
  • Nausea and vomiting
  • Hair loss
  • Fluid retention
  • Vaginal yeast infection

These are not all the possible side effects of estrogens. For more information, ask your healthcare
provider or pharmacist.