Treatment With ESTRING® (estradiol vaginal ring)

Getting Started

Support at every step

Beginning treatment starts with:

1Asking your doctor about Estring
2Learning how to insert and remove Estring
3Saving on your prescription

Doctor Discussion Guide

Talking to your doctor about Estring

Having the conversation about moderate to severe vaginal symptoms after menopause can be uncomfortable, but it doesn’t need to be. If you are postmenopausal and want to talk to your doctor about possible treatment with Estring but you aren’t sure how to start, here are some tips to get the conversation going:

“I’m feeling some real discomfort down there [in my vagina]. What can Estring do to help?”
“I’m looking for a treatment option I don’t have to apply daily. Can we discuss Estring?”
"I expected hot flashes and night sweats but I didn't know about vaginal symptoms. Can you explain more about vaginal symptoms due to menopause and what the treatment options are?"

Download and print our doctor discussion guide before your next appointment.

DOCTOR
DISCUSSION GUIDE

How to use Estring

Getting comfortable with inserting Estring

Please see the Instructions For Use within the Patient Information. For more information, this video will show you how to insert and remove Estring^® (estradiol vaginal system). It can be done by you or, if you'd prefer, by your doctor.

ESTRING PROVIDES RELIEF OF LOCAL SYMPTOMS OF MENOPAUSE ONLY

Download your copy of our insertion and removal guide.

INSERTION &
REMOVAL GUIDE

Save on your prescription

Saving on your Estring prescription

With an Estring Savings Card, you may be eligible to pay as little as $45* for each of your next 4 Estring prescriptions.

See Savings
Offer

*Estring Terms and Conditions apply.

By using the Estring Co-Pay Card, you acknowledge that you currently meet the eligibility criteria and will comply with the terms and conditions described below:

Patients are not eligible to use this card if they are enrolled in a state or federally funded insurance program, including but not limited to Medicare, Medicaid, TRICARE, Veteran Affairs health care, a state prescription drug assistance program, or the Government Health Insurance Plan available in Puerto Rico (formerly known as “La Reforma de Salud”).
Patient must have private insurance. Offer is not valid for cash paying patients. The value of this Co-Pay Card is limited to $100 per use or the amount of your co-pay, whichever is less.
Maximum savings of $400 per calendar year.
This Co-Pay Card is not valid when the entire cost of your prescription drug is eligible to be reimbursed by your private insurance plan or other private health or pharmacy benefit programs.
You must deduct the value of this Co-Pay Card from any reimbursement request submitted to your private insurance plan, either directly by you or on your behalf.
You are responsible for reporting use of the Co-Pay Card to any private insurer, health plan, or other third party who pays for or reimburses any part of the prescription filled using the Co-Pay Card, as may be required. You should not use the Co-Pay Card if your insurer or health plan prohibits use of manufacturer Co-Pay Card.
You must be 18 years of age or older to redeem the Co-Pay Card.
This Co-Pay Card is not valid where prohibited by law.
The benefit under the Co-Pay Card program is offered to, and intended for the sole benefit of, eligible patients and may not be transferred to or utilized for the benefit of third parties, including, without limitation, third party payers, pharmacy benefit managers, or the agents of either.
Co-Pay Card cannot be combined with any other external savings, free trial or similar offer for the specified prescription (including any program offered by a third party payer or pharmacy benefit manager, or an agent of either, that adjusts patient cost-sharing obligations, through arrangements that may be referred to as “accumulator” or “maximizer” programs)
Third party payers, pharmacy benefit managers, or the agents of either, are prohibited from assisting patients with enrolling in the Co-Pay Card program.
Co-Pay Card will be accepted only at participating pharmacies.
This Co-Pay Card is not health insurance.
Offer good only in the U.S. and Puerto Rico.
Co-Pay Card is limited to 1 per person during this offering period and is not transferable.
A Co-Pay Card may not be redeemed more than once per 90 days per patient.
No other purchase is necessary.
Data related to your redemption of the Co-Pay Card may be collected, analyzed, and shared with Pfizer, for market research and other purposes related to assessing Pfizer’s programs. Data shared with Pfizer will be aggregated and de-identified; it will be combined with data related to other Co-Pay Card redemptions and will not identify you.
Pfizer reserves the right to rescind, revoke or amend this offer without notice.
Offer expires 12/31/2025

No membership fees apply. For help with the Estring Savings Card, call 1-800-631-1181, or write: Pfizer Inc, 235 East 42nd Street, New York, NY 10017, or visit www.pfizer.com.

ISI

Find out more collapse

Important Safety Information and Indication

Using estrogen alone may increase your chance of getting cancer of the uterus (womb). Report any unusual vaginal bleeding right away while you are using Estring. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus. Your healthcare provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, strokes, or dementia (decline in brain function).

Using estrogen alone may increase your chances of getting strokes or blood clots. Using estrogens with progestins may increase your chances of getting heart attacks, strokes, breast cancer, or blood clots.

Using estrogens, with or without progestins, may increase your chance of getting dementia, based on a study of women 65 years of age or older.

Estrogens should be used at the lowest dose possible, only for as long as needed. You and your healthcare provider should talk regularly about whether you still need treatment.

Estring should be removed after 90 days of continued use. If continuation of therapy is indicated, the flexible ring should be replaced. You and your healthcare provider should talk regularly about whether you still need treatment with Estring to control these problems.

Estring should not be used if you have unusual vaginal bleeding, have, or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. In general, the addition of a progestin is recommended for women with a uterus to reduce the chance of getting cancer of the uterus.

If you take thyroid medication, consult your healthcare provider, as use of estrogens may change the amount needed.

Serious, but less common side effects include heart attack, stroke, blood clots, dementia, breast cancer, cancer of the lining of the uterus, cancer of the ovary, high blood pressure, high blood sugar, gallbladder disease, liver problems, changes in your thyroid hormone levels, and enlargement of benign tumors of the uterus (fibroids).

Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you: new breast lumps; unusual vaginal bleeding; changes in vision or speech; sudden new severe headaches; severe pains in your chest or legs with or without shortness of breath, weakness and fatigue; memory loss or confusion.

Less serious, but common side effects include, headache, breast pain, irregular vaginal bleeding or spotting, stomach or abdominal cramps, bloating, nausea and vomiting, fluid retention, and vaginal yeast infection.

Carefully follow instructions for use. If you have difficulty removing Estring, contact your healthcare provider right away.

Indication

Estring is a local estrogen therapy used after menopause to treat moderate to severe menopausal changes in and around the vagina. You and your healthcare provider should talk regularly about whether you still need treatment with Estring to control these problems.

Please see full Prescribing Information, including BOXED WARNING, and Patient Information.

Patients should always ask their doctors for medical advice about adverse events.

You may report an adverse event related to Pfizer products by calling 1-800-438-1985 (US only). If you prefer, you may contact the US Food and Drug Administration (FDA) directly. The FDA has established a reporting service known as MedWatch where healthcare professionals and consumers can report serious problems they suspect may be associated with the drugs and medical devices they prescribe, dispense, or use. Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.

Doctors may recommend alternative treatment options for their patients.